The interesting facts of Primary biliary cholangitis

Primary biliary cholangitis ( formerly called as primary biliary cirrhosis:

It is a chronic , progressive liver disease characterized by the autoimmune destruction of  intra hepatic bile ducts.Most commonly seen in female. Here are some interesting facts about PBC that may amaze you as a clinician or a medical doctor.These are some of the high yeild points of PBC:

1. Although its name suggests "cholangitis" many of us may be confused with the extrahepatic destruction ,but it destroys intra hepatic part of the bile duct.
2. Since it attacks bile ducts,it has to present with the features of obstructive jaundice.Likewise,the patient present with intense pruritis without any obvious jaundice in earlier courses 
3. Due to bile duct destruction, it causes hyperlipidemia, but again the rise in lipid is only HDL(which is cardioprotective in nature) and wont cause atherosclerosis
4. Another interesting fact is the disease causes metabolic bone disease resulting in osteopenia,however the disease wont cause malabsorption of vitamin D or calcium as the blood level are normal.Although in some articles, osteopenia is being linked with low serum vitamin D due to malabsorption .
   
   
   
   This is all the interesting facts that are high yeild to know, but it doesnot contain all the information.for details  click here
   the short video explaning the disease is here .